Question about number of sperm needed

July 24, 2008

Hello doctors:

Everything I've read says that only a small number of sperm from ejaculate actually make it to the egg and/or fallopian tubes, due to a number of factors. If this is true, why is it that having an IUI with less than a million sperm injected DIRECTLY INTO THE UTERUS and much closer to the egg, is unlikely to lead to conception? Why are the pregnancy rates low with that many motile sperm that are essentially getting a head start? I don't understand.

I had an IUI yesterday with 300,000 motile sperm, yet I was told this is unlikely to work. Kindly help me understand why this is.

THANKS.

July 24, 2008

Sperm not only have to be able to swim, they have to undergo several phases, such as capacitation, with hypermotility needed to burrow through the egg's shell...

When there's low numbers of sperm, many times they may also not be fully functional and capable of fertilizing the egg, and we know this...

This is why ICSI is primarily performed in IVF patients for this same fear

July 24, 2008

But I thought only the best of the best sperm were pulled from washing and good for insemination?

July 24, 2008

The best however in these cases, may still not be "good enough"

July 24, 2008

oh boy...not very reassuring.

July 24, 2008

HUGS!! and think POSITIVE!! it only takes that one strong swimmer..GOOD LUCK!! BABY DUST!

July 24, 2008

Thanks, Melissa. Anything can happen, I suppose. We'll do IVF/ICSI if we have to.

Hope you're well!

July 24, 2008

I am well !! and you will be too..I am a TRUE believer anything is posile it might take time but it will be so worth it..and it will happen .. :)

July 24, 2008

I hope you're right. Thanks, Melissa, and best of luck to you, too!

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