So what does PDG stand for? & is this going to help me geneticly select the embryos w/o the inversion? How long does that take to do before I can do IVF(if this 1 fails or in the future)? Thank you doctor!!!
miscarriages is from my chromosome 9 inversion?!?!
July 14, 2008
What do you know about chromosome 9 inversion?! And what can be done about it?! Is IVF the only way around it?!
Here's what has been going on w/me:Well my beta level was 15,876.8 hcg 7/9/08 & my ultrasound mesaured the baby @ 5w 6d... so my due date is now 3/5/09. Also I got some bad news from my RE on 7/9/08...he said that after testing & research...he's pretty sure the main cause of my recurrent miscarriages is from my chromosome 9 inversion (which is rare...& I knew about the inversion & @1 point we thought we might need IVF cuz of what a nurse had told us & then my RE had made us thought that it wasn't gonna require
IVF...even more rare is the fact both my husband & I have it...which us both having it...instead of only 1 of us having it is a good thing believe it or not!)& that since we both have it it's better than only 1 of us having it because their being more possibilities for the chromosomes to match up right...he told me the only reason my daughter was born(miracle!!)is because I just happened to drop an egg w/a set of chromosomes w/o the inversion..so it matched up....which is the only way she was able to surive cuz I needed to have 2 sets of chromosomes w/o inversion...& if I had dropped the chromosome 9 inversion it would have matched up wrong...& end in m/c. Well since my husband & I both have it the chances are better for it to match up(like a puzzle)...we either have to both give a set w/o inversion or both give a set w/inversion(if we did that though the child when it grew up would have infertility probs due to inversion), but if we both gave diff sets...1 w/o inversion & 1 w/inversion...it would mismatch...& I'll m/c again(or I think if it survived I might have a baby w/a lot of birth defects...according to 1 website...here's the link to the table that shows the type of defects:
:http://www.ijhg.com/viewimage.asp?img=IndianJHumGenet_2006_12_3_129_29856_4.jpg if it has that prob...it might have physical &/(or)mental probs,...but my RE had advised me that those type of probs depends on the serverity of the inversion & that are's weren't severe...but to me this inversion is rare...so since little is known...there are conflicting ideas...since there have been limted clinical studies).
The RE said that there's a test he could do @ 12weeks to find out if it's mismatched or not,...but by 12 weeks if the baby has that prob...I'll m/c b4 12weeks...& if I make it to 12weeks for testing...then I'm outta the clear & it doesn't have that problem. Also he suggested some meds to take,....but there was no guarantee it would work or help prevent m/c & have me carry full-term, but still I had to take time to take these meds into consideration b4 I ordered them & self-pay for it. Well today's 7/14/08 & I decided to order the meds...so tomorrow on 7/15/08 I have an appt w/my RE for prob another u/s(probably)& blood work(of course),& I'm gonna ask my RE how to take the meds when & how often. The new meds I was prescribed are: Lovenox 30MG (a blood thinner injection for my blood cloting problem..there's a side effect..of not being able to stop bleeding if I get injured though which really scares my husband & I!!!),Chorionic Gonado (HCG
multi-dose injection to help keep my HCG levels up...I assume??)...anywayz I'll have more info on 7/15/08 @ my appt.
All of this has been really hard on me...the 3 m/c's...the high risk pregnancy...the feeling of helplessness...cuz the RE can't do much for me till I get outta 1st trimester!!! It's so depressing to not know if ur baby will live or die...& the RE can't do anything about it really..since it's a chromosomal abnormalty...& I really wish there was more they could do for my baby & more research on it...& more info known!! Also I think even if I make it to 12weeks I still want the test...cuz I wanna know what I'm up against...where the baby has problems..or not we will love it uncondtionaly...I just want to be prepared if there's a problem...so I'm not suprised! Everyone pray for me!!!
Here's what has been going on w/me:Well my beta level was 15,876.8 hcg 7/9/08 & my ultrasound mesaured the baby @ 5w 6d... so my due date is now 3/5/09. Also I got some bad news from my RE on 7/9/08...he said that after testing & research...he's pretty sure the main cause of my recurrent miscarriages is from my chromosome 9 inversion (which is rare...& I knew about the inversion & @1 point we thought we might need IVF cuz of what a nurse had told us & then my RE had made us thought that it wasn't gonna require
IVF...even more rare is the fact both my husband & I have it...which us both having it...instead of only 1 of us having it is a good thing believe it or not!)& that since we both have it it's better than only 1 of us having it because their being more possibilities for the chromosomes to match up right...he told me the only reason my daughter was born(miracle!!)is because I just happened to drop an egg w/a set of chromosomes w/o the inversion..so it matched up....which is the only way she was able to surive cuz I needed to have 2 sets of chromosomes w/o inversion...& if I had dropped the chromosome 9 inversion it would have matched up wrong...& end in m/c. Well since my husband & I both have it the chances are better for it to match up(like a puzzle)...we either have to both give a set w/o inversion or both give a set w/inversion(if we did that though the child when it grew up would have infertility probs due to inversion), but if we both gave diff sets...1 w/o inversion & 1 w/inversion...it would mismatch...& I'll m/c again(or I think if it survived I might have a baby w/a lot of birth defects...according to 1 website...here's the link to the table that shows the type of defects:
:http://www.ijhg.com/viewimage.asp?img=IndianJHumGenet_2006_12_3_129_29856_4.jpg if it has that prob...it might have physical &/(or)mental probs,...but my RE had advised me that those type of probs depends on the serverity of the inversion & that are's weren't severe...but to me this inversion is rare...so since little is known...there are conflicting ideas...since there have been limted clinical studies).
The RE said that there's a test he could do @ 12weeks to find out if it's mismatched or not,...but by 12 weeks if the baby has that prob...I'll m/c b4 12weeks...& if I make it to 12weeks for testing...then I'm outta the clear & it doesn't have that problem. Also he suggested some meds to take,....but there was no guarantee it would work or help prevent m/c & have me carry full-term, but still I had to take time to take these meds into consideration b4 I ordered them & self-pay for it. Well today's 7/14/08 & I decided to order the meds...so tomorrow on 7/15/08 I have an appt w/my RE for prob another u/s(probably)& blood work(of course),& I'm gonna ask my RE how to take the meds when & how often. The new meds I was prescribed are: Lovenox 30MG (a blood thinner injection for my blood cloting problem..there's a side effect..of not being able to stop bleeding if I get injured though which really scares my husband & I!!!),Chorionic Gonado (HCG
multi-dose injection to help keep my HCG levels up...I assume??)...anywayz I'll have more info on 7/15/08 @ my appt.
All of this has been really hard on me...the 3 m/c's...the high risk pregnancy...the feeling of helplessness...cuz the RE can't do much for me till I get outta 1st trimester!!! It's so depressing to not know if ur baby will live or die...& the RE can't do anything about it really..since it's a chromosomal abnormalty...& I really wish there was more they could do for my baby & more research on it...& more info known!! Also I think even if I make it to 12weeks I still want the test...cuz I wanna know what I'm up against...where the baby has problems..or not we will love it uncondtionaly...I just want to be prepared if there's a problem...so I'm not suprised! Everyone pray for me!!!
They detected a heart beat on u/s everyone! It was 115 bpm! And my due date changed again...to the 3/6/09 which would make me 6w 4d?! My RE said that I should keep the due date according to my LMP not the size though...cuz the baby could just be growing @ a slightly diff rate...right now & will even out soon..so I should stick w/dd 3/8/09...until I get futher along which would make me 6w 2d?! Not sure what my beta was though...cuz the lab results after 1:30pm...arn't avaliable till the following day...so if I can get back on 2mmrow I'll post it(cuz I'll be outta town for a few days). Keep praying for me...I'll post more l8r...& more info the RE told me 2...don't feel like writing it all right now...lol.
July 14, 2008
You're right, there is no treatment for this and one has two options:
Try on your own hoping that the probability (1/4) of your pregnancies will be normal...keep on trying until this right combination occurs or
IVF+PGD where the proper embryos with the right chromosomes are transferred into your womb to try and prevent a miscarriage