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Preseed and KY jelly »
« Menopause

Concerns about fertility drugs

Copy_ram8
travelgrrl

July 16, 2007

I am 40 years old and am very concerned with multiple gestation and possible ethical/moral ramifications that can come with using fertility drugs. As much as possible, I would like to only become pregnant with only one child, maximum two, since there is an increase in problems for the children and the mother during a pregnancy with multiples. Upon doing research on Gonal-F, I’ve found out that 15-20% of pregnancies from drugs like Gonal-F and Follistim are twins and 5% are triplets or higher (I found that statistic from RESOLVE). That worries me a great deal. Plus the fact that I would be doing IUI instead of IVF, which there is more control in the multiple births because we are manually placing the eggs in the fallopian tubes, adds to my concern. My greatest fear is to become pregnant with multiples and then have to make a decision to terminate some of the fetuses to reduce the difficulties of the pregnancy and give the other fetuses greater chance of survival. That would be a difficult decision to make for anyone, but as a Catholic (or anyone who is religious), it would be doubly difficult ethically and morally. I would prefer not to put myself in that situation if I can help it.



I know that my RE's main objective is to get me pregnant and that’s he is being aggressive in his approach. But I won’t do it at any cost and I won’t be blind to any possible physical/emotional/moral dilemmas that can occur. Are there other fertility drugs that I can use that can produce an outcome that no more than twins will occur? I know that there are no guarantees, but maybe I should be more conservative in my approach, rather than being aggressive. I’ve used chlomid before, could that be an option again? Or if chlomid may be too weak, then is there something in between chlomid and Follistim/Gonal-F?



I want to make the best decision, with as much knowledge as possible and with the understanding of the consequences of my actions. I need to be able to make a decision I can live with – one with which I can have a clear conscience. Thanks for your help.

Details
  • Posted over 2 years ago
  • Last active over 2 years ago
  • 4 comments
  • Tags

    multiple, births, twins, fertility, drugs, iui, ivf, selective, reduction, abortion, clomid, gonalf, follistim, and catholic

Woman_4
MJ

July 16, 2007

My suggestion is that you only have 1 or 2 fertilized eggs implanted so that you will not have to make a choice you are not ready to make. Has your doctor discussed these options with you? If they suggest 6 to be implanted, then I would seriously consider a second option.
Autumn_leaves
Dr. Q

July 16, 2007

This is a common scenario that I discuss with many patients and something that is emphasized in many national meetins...how to reduce the probability of multiple births in order to decrease possible associated complications and/or avoid individual ethical dilemmas.

This is usually a greater problem in patients under the age of 37, who can create a large number of chromosomally normal eggs and thus find themselves in this predicament. It is true, however, that with IVF in younger patients, single embryo transfer can be contemplated to try and prevent twins. Things are different, however, when women turn 40.

The pregnancy rates are low using our best technology: IVF using high dose gonadotropins and transferring 3 or more embryos. Some of the better centers will report upto a 33% pregnancy rate, let alone live birth rate. Nationally, the average live birth rate in women doing IVF is between 10-15% per cycle. The rates you are quoted are not age specified...it is uncommon to have more than twins with any ART in women over 40....We RE's are highly content just to achieve a singleton pregnancy using aggressive approaches.

This said, pregnancies with IUI's are even lower, even if you are stimulated to make 6 follicles will be at best half the quoted national rate.

Statistically said, it is highly unlikely you'll have to make the types of decisions you're trying to avoid and in all honesty, clomid may be too weak to try. Indeed, even for IVF, the American Society for Reproductive Medicine (ASRM) who is actively trying to reduce the impact of multiple births, recommends that in this age group that up to 5 embryos be transferred. Many REs would be reluctant to only transfer 2 embryos since there is a high likelihood that most embryos in this group are chromosomally abnormal.

As you have been doing, have an open dialogue with your RE about this topic.
Woman_3
Jamie D...

July 28, 2007

I normally have a 28 day cycle.But since my last m/c I had a cycle Jan month after the D&C.and also feb07.But since then I have'nt came on my own.My dr started me on medroxyprogestrone to make me come down.She started me on 50mg of clomid days 5-9.Well she has not kept up with my blood work or ultra sound to check my follicules.Now I took 1 10mg pill,but started fealing sick so i took a digital test it came up positive now i'm scared to take the pill because she will not do a blood test.What should I do.
Autumn_leaves
Dr. Q

July 28, 2007

Hi Jamie,

I'm assuming the 10mg pill is the medroxyprogesterone and don't worry, no harm done. Is the digital test an OPK or a pregnancy test?

Many Ob's don't do blood work or ultrasounds or much more intervention, and that's Ok because that's within their scope of practicing medicine. Please let me know what test is positive and can better answer your questions.
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